Issn 2347-3614 Dissolution Rate Enhancement of Ketoprofen by Surface Solid Dispersion with Colloidal Silicon Dioxide

Surface solid dispersion with insoluble carriers is considered a recently developed technique, widely applied for the enhancement of solubility and dissolution of poorly water soluble drugs. The objective of this research article is to study the effect of surface solid dispersion of ketoprofen with colloidal silicon dioxide (Aerosil 200) on the dissolution rate. Surface solid dispersion (Adsorbate) containing increased amount of the carrier (1:1 and 1:2) were prepared by surface deposition of ketoprofen from alcoholic solution on the surface of aerosil 200. The prepared adsorbates were characterized by DTA, X-ray and the dissolution profiles were compared by model independent methods. The model independent parameters showed that, the dissolution profiles of adsorbates were greatly higher than that of untreated drug or physical mixtures. The increase in the dissolution rate of the adsorbate compared with untreated drug is due to the conversion of the drug form the crystalline state to the highly energetic amorphous state as proved by DTA and Xray. The surface solid dispersion proved to be efficient method for improving the dissolution of low water soluble drug which results in dramatic increase in the dissolution rate, rapid absorption, enhanced biological activity and reduced side effects.